Orlistat: advice, dosage, price & side effects

Orlistat: advice, dosage, price & side effects
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Orlistat is a prescribed drug to treat obesity or overweight who are associated with risk factors such as diabetes and heart disease.

Orlistat: dosage

The usual dosage of this treatment is one capsule with a glass of water, 3 times a day before, during or up to an hour after each meal.

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This medicine will only be effective if there is dietary fat in your meals. If you skip a meal or if it does not contain fats, it is not necessary to take a capsule.

This treatment must be taken in addition to a healthy diet, limited in calories, rich in fruits and vegetables and which on average 30% of the calories come from dietary fat. Your daily intake of fat, carbohydrate and protien should be devided between the 3 meals.

For better results, you should avoid eating foods containing fats betwween meals.

You must stop the treatment after 12 weeks if you have not lost at least 5 % of your initial weight.

It is important to know that taking a larger dosage of Orlistat does not bring any additional benefit.

Ingredients and composition

Active ingredient: Orlistat

Excipients: microcrystalline cellulose, sodium carboxymethyl starch type A, colloidal anhydrous silica, sodium lauryl sulfate, gelatin, titanium dioxide, indigotin.

How does Orlistat work?

The primary action of this treatment is very simple to understand. Fat from your diet is broken down by enzymes, called lipases in your stomach and intestines and absorbed into your body to be stored.

Orlistat works by inhibiting this process and will stop these enzymes from working correctly.

About a third of the fat you eat is blocked by orlistat. The unabsorbed fat will pass directly through your digestive system.

Is Orlistat really effective?

Many studies have highlighted the effectiveness of this drug. Five studies over two years have shown that 37% of people taking this drug against 19 % of people taking placebo pills lost at least 5 % of their initial weight after 12 weeks of treatment. It was taken in addition to a low-calorie diet for the duration of the study.

after a year of treatment, 49% of patients under the drug and 40% of patients under a placebo lost 10% or more of their initial weight.

A study over four years has shown that 60 % of people under Orlistat and 35 % under a placebo lost at least 5 % of weight after a 12 weeks treatment. After a year of treatment, 62% of patients taking this drug against 52% taking placebo pills lost 10% or more of their initial weight.

Among those who did not have a 5% weight loss compared to their initial weight after 12 weeks, only 5% of patients taking the drug and 4% of people taking placebo pills lost 10% or more of their initial weight after one year.

After a year of treatment, 41% of patients taking this drug against 21% of patients taking placebo pills lost 10% or more of their initial weight, with a difference of 9.7lb between each group.

After four years of treatment, 21% of patients taking Orlistat against 10% of patients taking placebo pills lost 10% or more of their initial weight, with a difference of 5.9lb between each group.

Comparing the five 2-year studies and the one 4-year study, more patients treated with Orlistat or with placebo, during the 4-year study, experienced a weight loss of at least 5% of their initial weight after 12 weeks and 10% after one year.

This difference is easy to explain. The five 2-year studies include a diet of four weeks, during which patients lost more than 5lb before starting treatment.

Results of the 4-year study have also demonstrated that weight loss achieved with this treatment delayed the development of type 2 diabetes during the study. The vast majority of diabetes cases were from the subgroup of patients with glucose intolerance, representing 21% of randomized patients.

In a multicenter study conducted in the US and Canada in parallel, double-blind, placebo-controlled groups, 539 obese adolescents were randomized to receive either 120 mg of this drug or a placebo, 3 times a day for 52 weeks, in combination a low-calorie diet and physical activities.

The primary endpoint was the change in BMI between the study starting date and the end of the study. The results were significantly higher in the group who took this medication. 9.5% of patients treated with this drug against 3.3% of placebo patients lost 10% or more of their body weight after one year with an average difference of 5.6lb between the two groups.

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Precautions of use


This medicine is contraindicated in the following cases:

  • Hypersensitivity to the active ingredient or to any of the components of this drug.
  • If you have liver disorders (cholestasis)
  • If you suffer from a malabsorption syndrome such as food absorption problems.
  • Breastfeeding
  • Pregnancy

Possible Drug Interactions

Orlistat may interact with other medicines or treatments:

  • Antidiabetic medicines prescribed for the treatment of type 2 diabetes (acarbose)
  • Anticoagulants (Warfarin for example)
  • Medications that weaken the immune system like cyclosporine
  • Levothyroxine and iodized salts
  • Drugs for Cardiac Arrhythmias (Amiodarone)

Additional warnings:

  • If you are taking or have recently taken any other treatment, including those obtained without a prescription, inform your doctor.
  • This treatment may change your stool due to the elimination of undigested fat in the stool.
  • The occurrence of diarrhea can reduce the effectiveness of oral contraception. It is therefore advisable to use a complementary method of contraception.

Possible Side Effects

Side effects have been reported while taking this treatment:

  • Diarrhea
  • Flatulence
  • Headache
  • Stomach pain
  • Fatty or oily stools
  • Low blood sugar
  • Rectal pain
  • Fecal incontinence
  • Bloating
  • Irregular period
  • Fatigue
  • Problems with your teeth or gums
  • Allergic reactions (itching, skin rash, severe breathing difficulties, nausea, vomiting, and dizziness).
  • Rectal bleeding
  • Elevated liver enzymes
  • Gallstones
  • Hepatitis
  • Pancreatitis
  • Rashes
  • Nephropathy

If you notice any other side effects during your treatment, consult your doctor.

Frequently Asked Questions found on forums about Orlistat

These are the answers to the most frequently asked questions, received by our readers. If you can not find an answer to your question in the list below, please contact us, or talk to your doctor!

What is the dosage of this treatment?

You must take 3 capsule per day, during or up to an hour after your meal.

Can I get Orlistat without prescription?

No. You must have a prescription to get this drug.

I am pregnant. Can I take the treatment?

This drug is not recommended when pregnant. If you realize you are pregnant while taking this treatment, contact your doctor.

Does my insurance cover Orlistat?

Most insurers do not cover weight loss treatment.

How to store this medicine at home?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat, moisture (not in the bathroom), and light.

For how long should I take this treatment before seeing results?

This treatment must be taken for 12 weeks. If you did not lose at least 5% of your initial weight, you should stop the treatment.

Where to buy this drug at the best price?

You can either buy this treatment in a pharmacy or buy it online on a serious site. We recommend you to trust our partner pharmacy Treated.com, which offers competitive prices on products made in the European Union. Free shipping within 24h.

Where to buy Orlistat 120mg online at the best price?

You can buy Orlistat in a pharmacy if you have a prescription.

But you can also buy it online. buying this drug online has become very popular the last few years. Either for a renewal or because you can not get to a pharmacy, the internet is an easier and quicker solution.

As the sales of this drug online kept on increasing, many websites started to offer this treatment. The problem is, only a few of them are serious and reliable. They allow you to buy the treatment in only a few clicks and without asking you about your health.

Of course, we don’t recommend you these websites. Feedbacks on these websites are more than negatives, and the drug you ordered is probably fake. Not only it won’t be effective, but you’ll lose money and put your health at risk.

“Do not put your health at risk, do NOT buy your products on no-official websites.”

Orlistat is available on many websites.
Only few of them, like Treated.com are certified to sell this drug.

We can recommend you Treated.com, whose reputation was glorified due to its services. Know that you will not be able to buy any medicine without filling up a form about your health. Which makes it a reliable website. You must indicate all the treatments you are currently taking or recently taken. You must then, wait until a certified doctor validates your order. Once validated, your order is sent to a pharmacy.

This pharmacy will be in charge to send you Orlistat within 24 hours.

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Orlistat is currently one of the only approved weight loss treatment by the FDA in the United States. This drug is not perfect (see side effects above), But many studies have shown that it is one of the most effective.

What we like:

  • Quick results.
  • Cheaper than the Xenical version.
  • Results are scientifically proven.

What we do not like:

  • Side effects while taking treatment.
  • Treatment must be taken in addition to a low-calorie diet. It isn’t a miracle product!



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